ACM Pivotal - Pharma Services, Clinical Trials, Contract Research, Diagnostic Services

Clinical Insight, a series of technical reports brought to you by ACM-Pivotal, is written by our team of global central lab experts on issues effecting clinical testing today. Based on their knowledge and experience with safety and specialty testing, our experts provide detailed information concerning current methodology, specimen requirements, and reference ranges on new and specialized tests. In Clinical Insight, our experts take it one step further to provide their opinions on the clinical significance of specific tests and how they can impact your clinical trial. The Use of Liquid-based Collection Methods for Women's Health Screening - NEW This issue reports on the advantages of liquid-based collection methods for not only cervical cancer screening, but also for sexually transmitted diseases. Includes analysis on current HPV, Chlamydia and Neisseria Gonorrhoeae testing. Flow Cytometry’s Central Role in Diagnosis of PNH Flow cytometry has replaced the Ham test as the gold standard technique for diagnosing patients with Paroxysmal Nocturnal Haemoglobinuria (PNH). This report, written by Clare Walker, MSc, Chief Clinical Lab Scientist, highlights the significant contributions flow cytometry has made in defining phenotypes of PNH. Understand Physiological Processes between Energy Metabolism and Appetite Regulation with Tests With the worldwide rise of obesity and metabolic diseases, labs should conduct ongoing test monitoring to see what may be of value for obesity. This report covers which tests are well-established and which provide beneficial results. Nephrotoxicity Testing in Clinical Trials to Improve Patient Safety This issue presents newer procedures for the evaluation of kidney function such as the Modification of Diet in Renal Disease (MDRD)2 equation and Cystatin C in the assessment of kidney function in non transplant patients.